Original Articles Effects of Ciprofloxacin on Foetal Hepatocytes
نویسندگان
چکیده
Early clinical pharmacology studies of oral and parenteral form of ciprofloxacin were begun shortly after the drug was discovered in Germany in 1982. The clinical trials programme for the efficacy of intravenous ciprofloxacin began in the USA in late 1985 and expanded throughout 1986, 1987 and April 1988. A new drug application for intravenous ciprofloxacin was submitted to the United States Food and Drug Administration.1 Ciprofloxacin is a fluorinated quinolone that is broad spectrum antibacterial agent. It is recommended for the treatment of infections caused by susceptible bacteria in lower respiratory tract, skin, bone and joint, urinary tract infections, and infectious diarrhoea.2 Although ciprofloxacin is contra-indicated in pregnancy and children3 but the drug is used unchecked, which may be prohibited by the government under rules. This study was done to evaluate the effects of ciprofloxacin administration during gestation on morphology of liver parenchyma in prenatal laboratory animals, i.e., foetuses of Wistar albino rats.
منابع مشابه
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